I-Proteomics ibandakanya ukusetshenziswa kobuchwepheshe bokulinganisa kwawo wonke amaprotheni akhona kuseli, izicubu noma into ephilayo.Ubuchwepheshe obusekelwe ku-Proteomics busetshenziswa ngezindlela ezihlukahlukene ezilungiselelweni ezihlukene zocwaningo njengokutholwa kwezimpawu zokuxilonga ezihlukahlukene, abantu abazoklama imithi yokugoma, ukuqonda izindlela ze-pathogenicity, ukuguqulwa kwamaphethini okukhuluma ngokusabela kumasignali ahlukene kanye nokuchazwa kwezindlela zamaprotheni ezisebenzayo ezifweni ezihlukahlukene.Njengamanje, ubuchwepheshe be-quantitative proteomics buhlukaniswe ikakhulukazi ngamasu e-TMT, Amahhala Elebula kanye ne-DIA.