I-BMKGENE inikeze inqwaba yezinsizakalo zokulandelana nokuhlaziya i-RNA yalolu cwaningo: Ama-adipocyte angena amanxeba awawona ama-myofibroblast.
Lesi sihloko sanyatheliswa ku-Nature Communications, sihlola i-plasticity engaba khona yama-adipocytes nama-fibroblasts ngemva kokulimala kwesikhumba.Usebenzisa ukulandelelwa kohlu lofuzo kanye nesithombe esibukhoma kuzilandiso kanye nasezilwaneni ezilimele, qaphela ukuthi ukulimala kubangela isimo sesikhashana sokufuduka kuma-adipocyte anamaphethini okufuduka kwamaseli ahluke kakhulu kanye nokuziphatha okuvela kuma-fibroblasts.
Ngaphezu kwalokho, ama-adipocyte afudukayo, awafaki isandla ekwakhekeni kwezibazi futhi ahlala engezona i-fibrogenic in vitro, in vivo, futhi lapho efakelwa amanxeba ezilwaneni.Kafushane, ama-adipocyte afudukayo ngenxa yokulimala ahlala ekhawulelwe kulayini futhi awahlangani noma ahlele kabusha abe yi-fibrosing phenotype.Lokhu okutholakele kuthinta kakhulu amasu ayisisekelo nawokuhumusha emkhakheni wezokwelapha ovuselelayo, okuhlanganisa ukungenelela komtholampilo kokulungisa amanxeba, isifo sikashukela, kanye ne-fibrotic pathologies.
Chofoza lapha ukuzefunda kabanzi ngalolu cwaningo
Isikhathi sokuthumela: Aug-29-2023