I-BMKGENE inikeze izinsiza zokulandelana ze-RNA ezinde ezingafaki amakhodi esihlokweni esithi “I-nanoformula ye-zoledronic acid ne-calcium carbonate iqondise ama-osteoclast futhi ihlehlisa ukukhumuzeka kwamathambo”, eyashicilelwa ku-Biomaterials, lapha, i-OCs' microenvironment-responsive nanoplatform-HMCZP iyathuthukiswa.
Ucwaningo lubonisa ukuthi i-HMCZP iphumelela kakhulu ekuvimbeleni umsebenzi wama-OC avuthiwe futhi ihlehlise ukulahleka kwethambo lesistimu kumagundane ane-ovariectomized uma kuqhathaniswa nokwelashwa komugqa wokuqala.I-High-throughput RNA sequencing (RNA-seq) iveze ukuthi i-HMCZP ingehlisa-iqondise ithagethi ebalulekile ye-osteoporosis, i-tartrate-resistant acid phosphatase (TRAP), nezinye izinhloso zokwelapha ezingaba khona.Lokhu okutholakele kusikisela ukuthi ukusebenzisa i-nanoplatform ehlakaniphile eqondiswe kuma-OCs kuyisu elithembisayo lokwelashwa kwe-osteoporosis.
Chofozalaphaukuze ufunde kabanzi ngalolu cwaningo.
Isikhathi sokuthumela: Dec-20-2023