I-BMKGENE ihlinzeke ngezinsizakalo zokulandelana kwe-spapatial transcriptome ocwaningweni "I-STEEL inika amandla ukucaciswa kwesinqumo esiphezulu sedatha ye-spatiotemporal transcriptomic", eyashicilelwa kokuthi Briefings in Bioinformatics.
Lolu cwaningo luphakamise i-algorithm esekelwe ekufundeni engagadiwe futhi ehlukahlukene, i-Spatial Transcriptome cEll typE clustering (STEEL), ehlonza izizinda ezisuka ku-transcriptome yendawo ngokuhlanganisa ubuhlalu obubonisa womabili amaphrofayili wokuvezwa kofuzo afana kakhulu kanye nebanga lendawo eliseduze ngendlela yamagrafu.
Ukuhlolwa okuphelele kwe-STEEL kudathasethi ye-transcriptomic yendawo kusuka kuplathifomu ye-10X Visium kukhombisa ukuthi ayifezi nje kuphela isinqumo esiphakeme ukuze ibonise izakhiwo ezinhle zobuchopho begundane kodwa futhi ivumela ukuhlanganiswa kwamaslayidi ezicubu eziningi ahlaziywe ngamanye abe esikhulu.
Ngokuthuthuka kobuchwepheshe be-spatial transcriptome, indlela yethu izosebenza kahle ekuhlonzweni kwesizinda kanye nokwakhiwa kabusha kwe-atlas yesisho sofuzo.
Chofozalaphaukuze ufunde kabanzi ngalolu cwaningo.
Isikhathi sokuthumela: Oct-20-2023