I-BMKGENE ihlinzeke ngezinsizakalo zokulandelana kwe-transcriptome yobude obugcwele kulolu cwaningo : Ukulandelana kwe-transcriptome yobude obugcwele be-lymphocyte kusabela ku-IFN-γ yembula impendulo yokuzivikela egobile ye-Th1 ku-flounder (Paralichthys olivaceus), eyashicilelwa ku-Fish & shellfish immunology.
Kulolu cwaningo, ukulandelana kobude obugcwele be-transcriptome kwenziwa ukuze kuhlaziywe izakhi zofuzo ezivezwe ngokuhlukile (DEGs) nezindlela zokubonisa ku-IFN-γ ama-lymphocyte avuselelwe e-flounder (Paralichthys olivaceus), i-Th1 kanye ne-Th2 indlela yokuhlukanisa amaseli yathuthukiswa ngokuphawulekayo kusuka ku-DEGs, futhi izakhi zofuzo endleleni yokuhlukanisa amaseli e-Th1 alawulwa futhi aqinisekiswa.Ngokuvumelana nalokho, ukuhluka kwezakhi zomaka zokuhlukanisa amaseli e-Th1 namaseli e-CD4 + aphenywa ngemva kokukhuthazwa kwe-IFN-γ, imiphumela yaqinisekisa ukuthi i-CD4 + T lymphocyte yanda kakhulu ngemva kokugqugquzelwa kwe-IFN-γ, ehambisana nezakhi zofuzo eziyisishiyagalombili eziphawulekayo zokuvuselela kanye nokukhula kwe-T-bet expression in lymphocytes.
Ekuphetheni, imiphumela yembule ukungeniswa kwe-IFN-γ ku-Th1-uhlobo lwe-immune impendulo, ihlinzeka ngemibono yamanoveli ekuhlukaniseni ama-CD4 + T lymphocyte ku-teleost.
Chofozalaphaukuze ufunde kabanzi ngalolu cwaningo.
Isikhathi sokuthumela: Oct-30-2023