I-BMKGENE inikeze i-ONT yokulandelana kwe-nanopore RNA efundeke isikhathi eside kanye nesevisi ye-ATAC-seq yocwaningo “ukwenziwa kusebenze kwe-Epigenetic kanye nokubhala okubhaliwe kwe-secretory kinase FAM20C njenge-oncogene ku-glioma”, eyashicilelwa ku-《Journal of Genetics and Genomics》.
Lolu cwaningo lwakha i-atlas ye-transcriptome yobude obugcwele kuma-gliomas abhanqiwe futhi yabona ukuthi izakhi zofuzo ezingama-22 zilawulwa i-transcriptome yobude obugcwele kanye nokuhlaziya okuhlukile kwe-APA.Ukuhlaziywa kwedatha ye-ATAC-seq kuveza ukuthi yomibili i-FAM20C ne-NPTN ziyizakhi zofuzo zehabhu ezinokuvuleka kwe-chromatin nokuveza okuhlukile.
Ngaphezu kwalokho, izifundo ze-in vitro kanye ne-vivo ziphakamisa ukuthi i-FAM20C igqugquzela ukwanda kanye ne-metastasis yamaseli e-glioma.Ngaleso sikhathi, i-NPTN, uhlobo olusha lokucindezela umdlavuza, luphikisana nomsebenzi we-FAM20C ngokuvimbela kokubili ukwanda nokufuduka kwe-glioma.Ukuvinjwa kwe-FAM20C ngokwenza amasosha omzimba angathathi hlangothi kubangela ukuhlehla kwezimila ze-xenograft.Ngaphezu kwalokho, i-MAX, BRD4, MYC, kanye ne-REST zitholakala njengezici ezingaba khona zokulawula i-FAM20C.
Ihlanganiswe ndawonye, le miphumela yembula indima ye-oncogenic ye-FAM20C ku-glioma futhi iveza ukukhanya okusha ngokwelashwa kwe-glioma ngokuqeda i-FAM20C.
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Isikhathi sokuthumela: Oct-20-2023