I-BMKGENE ihlinzeke ngezinsizakalo zokulandelana kwe-spapatial transcriptomics yalolu cwaningo: i-Drosophila homologue engaba khona ye-GPCRs yokunamathela kwezilwane ezincelisayo, ibandakanyeka ekuphenduleni kwe-antitumor kumaseli e-oncogenic ajovwe ezimpukaneni, eyashicilelwa ku-PNAS, mthl1.
Kulolu cwaningo, izimpukane zesilisa ezindala zajovwa ngama-OC, futhi ukulandelana kwe-spatial transcriptome kuzimpukane eziqandisiwe kwenziwa.Ukujova ama-OC ezimpukaneni zamadoda amadala kudala ukusabela okuqinile kombhalo ezimpukaneni ezifaka ikakhulukazi amajini afaka amaphrotheni e-bona fide G-coupled, phakathi kwawo ufuzo lwe-methusela-like 1 luvelele.
Ngenhlanganisela yokuguqulwa kofuzo kwesakhi sofuzo se-mthl1 (ukulahleka kokusebenza kanye nokuvezwa ngokweqile kwe-mthl1), kubhalwe ukuthi ngempela lolu fuzo lunomphumela wokunqanda ukwanda.Ngaphezu kwalokho, bonisa ukuthi i-mthl1 ilawula ukuvezwa kwenani elikhulu lezakhi zofuzo ezibhalwe ngekhodi zama-chemoreceptors kanye nofuzo abathintekayo ekulawuleni ukuthuthukiswa.Ichaze izindlela zokuzivikela zezimpukane ngokumelene namathumba lapho kungekho ukuvikeleka okuguquguqukayo.
Chofoza lapha ukuze ufunde kabanzi mayelana nalolu cwaningo
Isikhathi sokuthumela: Aug-10-2023