I-BMKGENE ihlinzeke ngezinsizakalo zokulandelana kwe-Hi-C zalolu cwaningo: Ukuhlukaniswa kwe-3D nokuhlelwa kabusha kwe-genome kunikeza imininingwane nge-pathogenesis yesifo sesibindi esinamafutha angenatshwala (NAFLD) ngokulandelana okuhlanganisiwe kwe-Hi-C, i-Nanopore, ne-RNA, eyashicilelwa ku-Acta Pharmaceutica Sinica. B.
Kulolu cwaningo, ukuhlolwa kwe-High-throughput chromosome conformation (Hi-C), ukulandelana kwe-Nanopore, kanye nokuhlolwa kwe-RNA-sequencing (RNA-seq) kwenziwa esibindini samagundane avamile kanye ne-NAFLD.
Ukwehluka okuhlonziwe ezinkulungwaneni zezifunda kuyo yonke i-genome ngokuphathelene nenhlangano ye-chromatin ye-3D nokuhlelwa kabusha kwe-genomic, phakathi kwamagundane avamile kanye ne-NAFLD, futhi kwavezwa ukungasebenzi kahle kofuzo okuvame ukuhambisana nalokhu kuhlukahluka.Izakhi zofuzo ezihlosiwe ezihlosiwe zikhonjwe ku-NAFLD, zithintwe ukuhlelwa kabusha kofuzo kanye nokuphazamiseka kwenhlangano yendawo.
Okutholakele okusha kunikeza ukuqonda ezindleleni zenoveli ze-NAFLD pathogenesis futhi kunganikeza uhlaka olusha lomqondo wokwelashwa kwe-NAFLD.
Chofozalaphaukuze ufunde kabanzi ngalolu cwaningo.
Isikhathi sokuthumela: Oct-30-2023