circ-rna

I-RNA eyindilinga(circRNA) iwuhlobo lwe-RNA engafakwanga ikhodi, esanda kutholwa inendima ebalulekile kumanethiwekhi okulawula ahilelekile ekuthuthukisweni, ukumelana nemvelo, njll. Ihlukile kuma-molecule e-RNA aqondile, isb mRNA, lncRNA, 3′ kanye no-5′. iziphetho ze-circRNA zihlanganiswe ndawonye ukuze zakhe isakhiwo esiyindilinga, esiwasindisa ekugayeni kwe-exonuclease futhi azinze kakhulu kuneningi le-RNA ewumugqa.I-CircRNA itholwe inemisebenzi eyahlukahlukene ekulawuleni ukubonakaliswa kofuzo.I-CircRNA ingenza njenge-ceRNA, ebopha i-miRNA ngokuncintisana, eyaziwa ngokuthi isipontshi se-miRNA.Inkundla yokuhlaziya ukulandelana kwe-CircRNA inika amandla ukwakheka kwe-circRNA nokuhlaziywa kwenkulumo, ukubikezela okuhlosiwe nokuhlaziya okuhlangene nezinye izinhlobo zama-molecule e-RNA.