DNA methylation jẹ ọkan ninu awọn iyipada epigenetic ti a ṣe iwadi lọpọlọpọ.O ṣe ipa to ṣe pataki ni iduroṣinṣin genome, ilana transcription pupọ, ati idagbasoke abuda.Igbasilẹ ti awọn Jiini jẹ ipinnu nipasẹ ipo methylation wọn, pẹlu awọn ipele methylation kekere ti o ni nkan ṣe pẹlu ikosile pupọ ati awọn ipele methylation giga ti o ni nkan ṣe pẹlu ipalọlọ pupọ.
Iṣajọpọ gbogbo-genome bisulfite sequencing (WGBS) ati data RNA-seq ngbanilaaye fun itupalẹ okeerẹ ti genome ati transcriptome, ṣiṣafihan awọn ilana ilana apilẹṣẹ, ati idamọ awọn ilana imọ-jinlẹ aramada ati awọn ami-ara.Asopọ laarin transcriptome ati methylation lesese data le ti wa ni idasilẹ da lori awọn Jiini, ṣepọ mejeeji datasets lilo Jiini bi a Afara.
Itupalẹ yii ṣe iranlọwọ lati ni oye ibamu laarin DNA methylation ati ikosile pupọ, ṣe idanimọ awọn jiini ti o ni ipa nipasẹ methylation, ati ṣe iwadii awọn ipa iṣẹ ṣiṣe ni isalẹ.
Lero ọfẹ lati kan si BMKGENE fun awọn oye ti ko ni afiwe si iwadii epigenetic.
Akoko ifiweranṣẹ: Oṣu kejila-05-2023