I-BMKGENE ibonelele ngokulandelelana kwe-RNA eninzi kunye neenkonzo zokuhlalutya kolu phononongo: Inxeba lokungena kwi-adipocytes ayiyomyofibroblasts.
Eli nqaku lipapashwe kwiNxibelelwano yeNdalo, iphonononga iplastiki enokubakho ye-adipocytes kunye ne-fibroblasts emva kokulimala kwesikhumba.Usebenzisa umkhondo womnombo wemfuza kunye nokucinga okuphilayo kwi-explants kunye nezilwanyana ezonzakeleyo, jonga ukuba ukwenzakala kubangela imeko yesikhashana yokufuduka kwi-adipocytes eneendlela ezahlukeneyo zokufuduka kweeseli kunye nokuziphatha okuvela kwi-fibroblasts.
Ngaphaya koko, ii-adipocyte ezifudukayo, azinagalelo ekwakhekeni kwesiva kwaye zihlale zingeyo-fibrogenic kwi-vitro, kwi-vivo, naxa kutshintshelwa amanxeba kwizilwanyana.Isishwankathelo, i-adipocyte efudukayo ebangelwa ukulimala ihlala inqanyulwe kumgca kwaye ayiguquki okanye iphinde ihlelwe kwi-phenotype ye-fibrosing.Ezi ziphumo zinempembelelo ngokubanzi izicwangciso ezisisiseko kunye nokuguqulela kwintsimi yeyeza lokuvuselela, kubandakanywa ungenelelo lwezonyango lokulungiswa kwenxeba, isifo seswekile, kunye ne-fibrotic pathologies.
Cofa apha ukuzefunda ngakumbi malunga nesi sifundo
Ixesha lokuposa: Aug-29-2023