I-BMKGENE ibonelele ngeenkonzo zokulandelelana kwe-RNA ezinde ezingasebenzisi ikhowudi kwinqaku elithi "I-nanoformula ye-zoledronic acid kunye ne-calcium carbonate ijolise kwi-osteoclasts kwaye ibuyisela i-osteoporosis", eyapapashwa kwi-Biomaterials, apha, i-OCs 'microenvironment-responsive nanoplatform-HMCZP iphuhlisiwe.
Uphononongo lubonisa ukuba i-HMCZP isebenze ngakumbi ekuvimbeleni umsebenzi we-OCs okhulileyo kunye nokubuyisela ukulahleka kwethambo lenkqubo kwiigundane ze-ovariectomized xa kuthelekiswa nonyango lokuqala.Ukulandelelana kwe-RNA ephezulu (i-RNA-seq) ibonise ukuba i-HMCZP inokunciphisa-injongo ebalulekileyo ye-osteoporosis, i-tartrate-resistant acid phosphatase (TRAP), kunye nezinye iithagethi ezinokubakho zonyango.Ezi ziphumo zibonisa ukuba ukusebenzisa i-nanoplatform ehlakaniphile ejoliswe kwi-OCs sisicwangciso esithembisayo sonyango lwe-osteoporosis.
CofaAphaukufunda ngakumbi malunga nesi sifundo.
Ixesha lokuposa: Dec-20-2023