I-BMKGENE ibonelele ngeenkonzo zokulandelelana kwe-transcriptome ubude obupheleleyo kolu phononongo : Ukulandelelana kwe-transcriptome yobude obupheleleyo be-lymphocytes ukuphendula kwi-IFN-γ ityhila impendulo ye-immune ye-Th1 kwi-flounder (Paralichthys olivaceus), eyapapashwa kwi-Fish & shellfish immunology.
Kule sifundo, ulandelelwano olupheleleyo lwe-transcriptome lwenziwa ukuhlalutya i-genes echazwe ngokwahlukileyo (DEGs) kunye neendlela zokubonisa kwi-IFN-γ evuselela i-lymphocytes ye-flounder (Paralichthys olivaceus), i-Th1 kunye ne-Th2 i-cell differentiation pathway yaphuculwa ngokuphawulekayo kwi-DEGs, kwaye ufuzo kwindlela yokwahlula iiseli ze-Th1 zaye zalawulwa kwaye zaqinisekiswa.Ngako oko, iinguqu kwi-Th1 i-cell differentiation marker genes kunye neeseli ze-CD4 + zaphandwa emva kokuvuselela i-IFN-γ, iziphumo ziqinisekisile ukuba i-CD4 + T lymphocytes yanda kakhulu emva kokuvuselela i-IFN-γ, ihamba kunye ne-eight genes ephawulekayo yokunyuswa kunye nokunyuka kwe-T-bet expression in lymphocytes.
Ukuqukumbela, iziphumo zibonakalise ukungeniswa kwe-IFN-γ kwi-Th1-uhlobo lwe-immune impendulo, ukubonelela ngeembono ezintsha ekuhlukaniseni i-CD4 + T lymphocytes kwi-teleost.
CofaAphaukufunda ngakumbi malunga nesi sifundo.
Ixesha lokuposa: Oct-30-2023