I-BMKGENE ibonelele nge-ONT yolandelelwano lwe-nanopore RNA efunda ixesha elide kunye nenkonzo ye-ATAC-seq yophononongo "I-Epigenetic kunye nokubhala okubhaliweyo kusebenze kwe-secretory kinase FAM20C njenge-oncogene kwi-glioma", eyapapashwa kwi-《Journal of Genetics and Genomics》.
Olu pho nonongo lwakha i-atlas ye-transcriptome yobude obupheleleyo kwi-gliomas edibeneyo kwaye yaqaphela ukuba i-22 yemfuza ilawulwa yi-transcriptome yobude obupheleleyo kunye nohlalutyo oluhlukeneyo lwe-APA.Uhlalutyo lwedatha ye-ATAC-seq lubonisa ukuba zombini i-FAM20C kunye ne-NPTN ziyi-hub genes kunye nokuvuleka kwe-chromatin kunye nokubonakalisa umahluko.
Ngaphaya koko, izifundo ze-in vitro kunye ne-vivo zibonisa ukuba i-FAM20C ivuselela ukwanda kunye ne-metastasis yeeseli ze-glioma.Ngeli xesha, i-NPTN, ijini yenoveli yokucinezela umhlaza, ichasene nomsebenzi we-FAM20C ngokuthintela zombini ukwanda kunye nokufuduka kwe-glioma.Ukuvalwa kwe-FAM20C ngokwenza amajoni omzimba angathathi hlangothi kubangela ukuhlehla kwamathumba exenograft.Ngaphezu koko, i-MAX, i-BRD4, i-MYC, kunye ne-REST zifunyenwe njengezona zinto zinokuthi zisebenze kwi-FAM20C.
Xa zidibene, ezi ziphumo zityhila indima ye-oncogenic ye-FAM20C kwi-glioma kwaye zikhanyise ukukhanya okutsha kunyango lwe-glioma ngokubhangisa i-FAM20C.
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Ixesha lokuposa: Oct-20-2023