I-BMKGENE ibonelele ngolandelelwano lwe-RNA kunye neenkonzo zokuhlalutya kolu phononongo "I-Aspergillus fumigatus iqweqwedisa i-p11 yomntu ukuze ibuyisele i-phagosomes equlethe umngundo kwindlela engonakaliyo.“, eyapapashwa kwiCell Host & Microbe.
Isigqibo sokuba i-endosomes ingena kwindlela eyonakalisayo okanye yokuphinda isetyenziswe kwiiseli ze-mammalian zibaluleke kakhulu ekubulaweni kwe-pathogen, kwaye ukungasebenzi kwayo kunemiphumo ye-pathological.
Olu phononongo lufumanise ukuba i-p11 yomntu yeyona nto ibalulekileyo kwesi sigqibo.Iprotheyini ye-HscA ekhoyo kwi-condial surface ye-fungus ye-human-pathogenic fungus i-Aspergillus fumigatus anchors p11 kwi-conidia-containing phagosomes (PSs), ayibandakanyi umlamli we-PS wokuvuthwa kwe-Rab7, kwaye ibangela ukubopha i-exocytosis mediators Rab11 kunye ne-Sec15.Olu hlengahlengiso lubuyisela ii-PSs kwindlela engonakalisiyo, ivumela i-A. fumigatus ukuba ibaleke iiseli ngokuphuma ngaphandle kunye nokugxothwa kunye nokudluliselwa kwe-conidia phakathi kweeseli.
Ukubaluleka kweklinikhi kuxhaswa ngokuchongwa kwe-polymorphism ye-nucleotide eyodwa kwindawo engabonakaliyo kwi-gene ye-S100A10 (p11) echaphazela i-mRNA kunye nokubonakaliswa kweprotheni ekuphenduleni i-A. fumigatus kwaye ihambelana nokukhuselwa kwi-aspergillosis ye-pulmonary invasive.Ezi zinto zifunyanisiweyo zityhila indima ye-p11 ekulamleni ukuphepha ukungunda kwePS.
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Ixesha lokuposa: Sep-08-2023