I-BMKGENE ibonelele ngenkonzo yolandelelwano lwe-transcriptome kuphononongo “I-cascade nanoreactor yokuphucula unyango lwe-sonodynamic kumhlaza we-colorectal nge-synergistic ROS augment kunye nokuvalwa kwe-autophagy", eyapapashwa kwiNano Namhlanje.
Olu phononongo lujolise ekuphuculeni ukusebenza kakuhle kwe-antitumor yonyango lwe-sonodynamic (SDT) kumhlaza obala, ukuyila ngokwengqiqo i-cascade nanoreactor ngokubandakanya i-sonosensitizer Ce6 kunye ne-autophagy inhibitor chloroquine kwi-homologous tumor cell membrane-modified hollow polydopamine nanocarrier efakwe ngaphambili ngeplatinum. (ichongwe njenge CCP@HP@M).
Uhlalutyo lwe-RNA-seq luphinde lwaqinisekisa i-apoptosis kunye neendlela ze-ferroptosis ezibandakanyekayo kwi-CCP @ HP @ M unyango.Le nanoreactor ye-cascade iya kubonelela ngesicwangciso esithembisayo sokwandisa ukupheliswa kwe-SDT ngokuchasene namathumba ngokumodareyitha i-ROS kunye ne-autophagy.
CofaAphaukufunda ngakumbi ngeli nqaku.
Ixesha lokuposa: Sep-08-2023