I-BMKGENE ibonelele ngeenkonzo zokulandelelana kwe-Hi-C kolu phononongo: Ukulungiswa kwe-3D kunye nohlengahlengiso lwe-genome kubonelela ngolwazi kwi-pathogenesis yesifo sesibindi esinamafutha angenatywala (NAFLD) ngokulandelelana kwe-Hi-C, i-Nanopore, kunye ne-RNA, eyapapashwa kwi-Acta Pharmaceutica Sinica. B.
Kule sifundo, i-High-throughput chromosome conformation capture (Hi-C), i-Nanopore sequencing, kunye ne-RNA-sequencing (RNA-seq) i-assays yenziwa kwisibindi sesiqhelo kunye neegundane ze-NAFLD.
Ukwahluka okuchongiweyo kumawaka emimandla kuyo yonke i-genome ngokumalunga nombutho we-chromatin we-3D kunye nohlengahlengiso lwe-genomic, phakathi kweempuku eziqhelekileyo kunye ne-NAFLD, kunye nokuvezwa kwe-gene dysregulation rhoqo ehamba nolu lwahluka.Iijini ezijoliswe kumviwa zichongiwe kwi-NAFLD, zichatshazelwa luhlengahlengiso lwemfuza kunye nokuphazamiseka kwentlangano yendawo.
Iziphumo ezitsha zibonelela ngengqiqo kwiindlela ezintsha ze-NAFLD pathogenesis kwaye zinokubonelela ngesakhelo esitsha sengqiqo yonyango lwe-NAFLD.
CofaAphaukufunda ngakumbi malunga nesi sifundo.
Ixesha lokuposa: Oct-30-2023