DNA methylation ke e 'ngoe ea liphetoho tsa epigenetic tse ithutoang haholo.E bapala karolo ea bohlokoa botsitsong ba genome, taolo ea mongolo oa liphatsa tsa lefutso, le nts'etsopele ea sebopeho.Ho ngoloa ha liphatsa tsa lefutso ho khethoa ke boemo ba bona ba methylation, ka maemo a tlaase a methylation a amanang le polelo ea liphatsa tsa lefutso le maemo a phahameng a methylation a amanang le ho khutsisa liphatsa tsa lefutso.
Ho kopanya tatellano ea liphatsa tsa lefutso tse felletseng (WGBS) le data ea RNA-seq ho lumella tlhahlobo e felletseng ea genome le transcriptome, ho senola mekhoa ea taolo ea liphatsa tsa lefutso, le ho tsebahatsa mekhoa e mecha ea baeloji le li-biomarker.Kamano pakeng tsa data ea tatellano ea transcriptome le methylation e ka thehoa ho latela liphatsa tsa lefutso, ho kopanya li-dataset ka bobeli ho sebelisa liphatsa tsa lefutso e le borokho.
Tlhahlobo ena e thusa ho utloisisa kamano pakeng tsa DNA methylation le polelo ea liphatsa tsa lefutso, ho khetholla liphatsa tsa lefutso tse susumetsoang ke methylation, le ho batlisisa liphello tse tlaase tsa ts'ebetso.
Ikutloe u lokolohile ho ikopanya le BMKGENE bakeng sa lintlha tse ke keng tsa bapisoa le lipatlisiso tsa epigenetic.
Nako ea poso: Dec-05-2023