HORUMARINTA GENOME, PANGENOME
Waa maxay Pan-genome?
Cadaymaha la ururiyey waxay muujinayaan in kala duwanaanshaha noocyada kala duwan ee noocyada uu noqon karo mid weyn.Hal genome-ka mid ah ayaa ka fog inuu ku filan yahay inuu helo sawirka oo dhan ee macluumaadka hidde-sidaha ee hal nooc.Ujeedada daraasadda Pan-genome waa in la helo garaaf genomic oo dhammaystiran oo noocyo kala duwan ah oo lagu go'aamiyo xiriirka ka dhexeeya astaamaha iyo xeerarka hiddaha iyadoo la fulinayo genome de novo ee noocyo badan, taas oo u oggolaanaysa qoto dheer oo qoto dheer oo macdan ah oo kala duwan.
Isbeddellada Daraasadda Pan-genome
Jaantuska 1 Isbeddellada waraaqaha cilmi-baarista ee la daabacay ee Pan-genome.
Fiiro gaar ah: Shaxanku wuxuu muujinayaa natiijada qaadashada "pan-genome" oo ah ereyga muhiimka ah ee lagu baadho cinwaannada maqaallada lagu daabacay joornaalada taxanaha ah ee Dabeecadda, Unugga iyo Sayniska.
a.Waxyaalo badan oo laga soo akhriyay muunado badan ayaa la jaanqaadaya tixraaca kuwa aan toosnaynna waxa la isugu geeyaa qaybo cusub.Marka lagu daro safafkan cusub ee taxanaha tixraaca asalka ah, tixraac pangenome ayaa la dhisi karaa.Gobollada la kala bixi karo waxaa lagu go'aamiyaa iyadoo lagu salaynayo khariidadeynta dhammaan akhrinta dib loogu celiyo pangenome.
b.Kulanka De novo ee genome-yada kala duwanaanshaha badan ayaa u oggolaanaya dhammaan hababka isku-habboonaanta genome-ga si loo aqoonsado gobollada genomiga ee la kala tagi karo.
c.Garaaf-genome-ga waxaa laga dhisi karaa isugeynta genome-ga oo dhan ama iyadoo la adeegsanayo garaafyada de novo, kaas oo si hufan u keydiya macluumaadka kala duwan ee gobollada la kala bixin karo sida waddooyin gaar ah oo loo marayo garaafka.
Sida loo dhiso Pan-genome?
Jaantuska 2 Isbarbardhigga hababka pan-genome1
a.Waxyaalo badan oo laga soo akhriyay muunado badan ayaa la jaanqaadaya tixraaca kuwa aan toosnaynna waxa la isugu geeyaa qaybo cusub.Marka lagu daro safafkan cusub ee taxanaha tixraaca asalka ah, tixraac pangenome ayaa la dhisi karaa.Gobollada la kala bixi karo waxaa lagu go'aamiyaa iyadoo lagu salaynayo khariidadeynta dhammaan akhrinta dib loogu celiyo pangenome.
b.Kulanka De novo ee genome-yada kala duwanaanshaha badan ayaa u oggolaanaya dhammaan hababka isku-habboonaanta genome-ga si loo aqoonsado gobollada genomiga ee la kala tagi karo.
c.Garaaf-genome-ga waxaa laga dhisi karaa isugeynta genome-ga oo dhan ama iyadoo la adeegsanayo garaafyada de novo, kaas oo si hufan u keydiya macluumaadka kala duwan ee gobollada la kala bixin karo sida waddooyin gaar ah oo loo marayo garaafka.
Pan-genomes dhawaan la daabacay
● Kufsiga pan-genomes2
● Yaanyada pan-genomes 3
● Bariiska Pan-genome4
● Gabbaldayaha Pan-genome5
● Soybean Pan-genome 6
● Bariiska Pan-genome7
● Barley Pan-genome8
● Qamadiga Pan-genome9
● Masagada Pan-genome10
● Phytoplankton Pan-genome11
Tixraac
1. Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. Dhirta pan-genomes waa tixraaca cusub.Dhirta Nat.2020;6 (8):914-920.doi:10.1038/s41477-020-0733-0
2. Heesta JM, Guan Z, Hu J, iyo al.Siddeed genome oo tayo sare leh ayaa muujinaya naqshadaha pan-genome-ga iyo kala duwanaanshaha deegaanka ee Brassica napus.Dhirta Nat.2020;6 (1):34-45.doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, iyo al.Pan-genome-ga yaanyada ayaa daaha ka qaaday hiddo-sideyaal cusub iyo caleen naadir ah oo nidaamisa dhadhanka miraha.Nat Genet.2019;51 (6): 1044-1051.doi:10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, iyo al.Falanqaynta Pan-genome waxay muujinaysaa heerka kala duwanaanshaha genomic ee bariiska la beeray iyo kuwa duurjoogta ah [sixitaanka la daabacay ayaa ka muuqda Nat Genet.2018 Agoosto;50(8):1196].Nat Genet.2018;50 (2):278-284.doi:10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, iyo al.Falanqaynta pan-genome-ga gabbaldayaha waxay muujinaysaa in isku-dhafka uu beddelay nuxurka hidda-socodka iyo iska caabbinta cudurrada.Dhirta Nat.2019;5(1):54-62.doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, iyo al.Pan-Genome of Duurjoogta iyo Beeralayda Soy.Unug.2020;182 (1): 162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, iyo al.Falanqaynta Pan-genome ee 33 nooc oo bariis ah oo hidde ahaan kala duwan ayaa daaha ka qaadaya kala duwanaanshaha genomiga qarsoon [la daabacay online ka hor daabacaadda, 2021 May 25].Unug.2021;S0092-8674(21)00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, iyo al.Pan-genome-ka shaciirku waxa uu daaha ka qaaday dhaxalka qarsoon ee taranka isu beddelka.Dabeecadda.2020;588(7837):284-289.doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, iyo al.Unugyada qamadiga ah ee kala duwan ayaa muujinaya kala duwanaanshaha caalamiga ah ee taranta casriga ah.Dabeecadda.2020;588(7837):277-283.doi:10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, iyo al.Kala duwanaansho ballaadhan oo ka dhex jirta pan-genome ee hadhuudhka la beeray iyo duurjoogta [waxaa lagu daabacay online ka hor intaan la daabacin, May 2021].Dhirta Nat.2021;10.1038 / s41477-021-00925-x.doi:10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, iyo al.Phytoplankton pangenome waxay daaha ka qaadaysaa wareejinta hidde-sidaha tooska ah ee prokaryotic ee hawlo kala duwan.Sci Adv.2020;6(18):eaba0111.La daabacay 2020 Apr 29. doi:10.1126/sciadv.aba0111
Waqtiga boostada: Jan-04-2022