GENOME EVOLUTION, PANGENOME
Chii chinonzi Pan-genome?
Humbowo hwakaunganidzwa hunoratidza kuti musiyano pakati pemhando dzakasiyana dzemhando inogona kuve yakakura.Imwe genome imwe chete iri kure nekukwana kuti uwane mufananidzo wose weruzivo rwemajini emhando imwe chete.Chinangwa chePan-genome kudzidza ndechekuwana yakazara yakazara genomic girafu yemhando uye decode hukama pakati pehunhu uye genetic codes nekuitisa genome de novo kusangana kwemhando dzakawanda, izvo zvinobvumira yakadzika uye yakafara migodhi yekusiyana.
Maitiro ePan-genome Chidzidzo
Mufananidzo 1 Maitiro emapepa ekutsvagisa akaburitswa ePan-genome.
Ongorora: Huwandu hunoratidza mhedzisiro yekutora "pan-genome" sezwi rakakosha kutsvaga misoro yezvinyorwa zvakaburitswa muNature, Cell uye Science series majenari.
a.Maverengero kubva kumasamples akawanda anoenderana nereferensi uye asina kurongeka anounganidzwa kuita novel contigs.Nekuwedzera idzi novel contigs kune yekutanga referensi kutevedzana, pangenome referensi inogona kuvakwa.Matunhu anowanikwa anotemerwa zvichibva pamepu zvese zvinoverengerwa kumashure kune pangenome.
b.De novo kuungana kwema genomes ezvakawanda zvinogoneka inobvumira yakazara genome alignment nzira yekuona inoraswa genomic matunhu.
c.Iyo pan-genome graph inogona kuvakwa kubva kuzere genome alignments kana ne de novo graph gungano, iyo inochengetedza zvakasiana ruzivo rwakasiyana rwematunhu anoraswa senzira dzakasiyana kuburikidza negirafu.
Nzira yekugadzira Pan-genome?
Mufananidzo 2 Kuenzanisa kwepan-genome nzira1
a.Maverengero kubva kumasamples akawanda anoenderana nereferensi uye asina kurongeka anounganidzwa kuita novel contigs.Nekuwedzera idzi novel contigs kune yekutanga referensi kutevedzana, pangenome referensi inogona kuvakwa.Matunhu anowanikwa anotemerwa zvichibva pamepu zvese zvinoverengerwa kumashure kune pangenome.
b.De novo kuungana kwema genomes ezvakawanda zvinogoneka inobvumira yakazara genome alignment nzira yekuona inoraswa genomic matunhu.
c.Iyo pan-genome graph inogona kuvakwa kubva kuzere genome alignments kana ne de novo graph gungano, iyo inochengetedza zvakasiana ruzivo rwakasiyana rwematunhu anoraswa senzira dzakasiyana kuburikidza negirafu.
Munguva pfupi yapfuura Pan-genomes
● Rape pan-genomes2
● Tomato pan-genomes 3
● Rice Pan -genome4
● Sunflower Pan-genome5
● Soyabhinzi Pan-genome 6
● Rice Pan-genome7
● Bhari Pan-genome8
● Gorosi Pan-genome9
● Nyoro Pan-genome10
● Phytoplankton Pan-genome11
Reference
1. Bayer PE, Golicz AA, Scheben A, Batley J, Edwards D. Plant pan-genomes ndiwo mutsva.Vadivelu Comedy Nat Plants.2020;6(8):914-920.doi:10.1038/s41477-020-0733-0
2. Rwiyo JM, Guan Z, Hu J, nevamwe.Masere emhando yepamusoro genome anoratidza pan-genome architecture uye ecotype musiyano weBrassica napus.Vadivelu Comedy Nat Plants.2020;6(1):34-45.doi:10.1038/s41477-019-0577-7
3. Gao L, Gonda I, Sun H, nevamwe.Iyo tomato pan-genome inofumura majini matsva uye isingawanzo allele inodzora michero inonaka.Nat Genet.2019;51(6):1044-1051.doi:10.1038/s41588-019-0410-2
4. Zhao Q, Feng Q, Lu H, et al.Kuongorora kwePan-genome kunoratidza huwandu hwekusiyana kwegenomic mumupunga wakarimwa uye wemusango [kugadziriswa kwakadhindwa kunoonekwa muNat Genet.2018 Aug;50(8):1196].Nat Genet.2018;50(2):278-284.doi:10.1038/s41588-018-0041-z
5. Hübner S, Bercovich N, Todesco M, nevamwe.Sunflower pan-genome analysis inoratidza kuti hybridization yakachinja gene content uye kuramba zvirwere.Vadivelu Comedy Nat Plants.2019;5(1):54-62.doi:10.1038/s41477-018-0329-0
6. Liu Y, Du H, Li P, nevamwe.Pan-Genome Yemusango uye Yakarimwa Soybeans.Sero.2020;182(1):162-176.e13.doi:10.1016/j.cell.2020.05.023
7. Qin P, Lu H, Du H, nevamwe.Kuongororwa kwePan-genome kwemakumi matatu nematatu akasiyana-siyana mupunga anowanikwa anoratidza yakavanzika genomic kusiyana [yakaburitswa online isati yadhindwa, 2021 Chivabvu 25].Sero.2021;S0092-8674(21)00581-X.doi:10.1016/j.cell.2021.04.046
8. Jayakodi M, Padmarasu S, Haberer G, et al.Iyo bhari pan-genome inoratidza yakavanzika nhaka yekuchinja kubereka.Nature.2020;588(7837):284-289.doi:10.1038/s41586-020-2947-8
9. Walkowiak S, Gao L, Monat C, nevamwe.Mazhinji egorosi genomes anoratidza mutsauko wepasi rose mukurera kwemazuva ano.Nature.2020;588(7837):277-283.doi:10.1038/s41586-020-2961-x
10. Tao Y, Luo H, Xu J, nevamwe.Kusiyana kwakakura mukati mepan-genome yemhunga akarimwa uye yemusango [yakaburitswa online isati yadhindwa, 2021 Chivabvu 20].Vadivelu Comedy Nat Plants.2021;10.1038 / s41477-021-00925-x.doi:10.1038/s41477-021-00925-x
11. Fan X, Qiu H, Han W, nevamwe.Phytoplankton pangenome inoratidza yakakura prokaryotic horizontal gene kutamiswa kwemabasa akasiyana.Sci Adv.2020;6(18):eaba0111.Yakabudiswa 2020 Kubvumbi 29. doi:10.1126/sciadv.aba0111
Nguva yekutumira: Jan-04-2022