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BMKGENE yakapa huwandu hweRNA sequencing uye masevhisi ekuongorora echidzidzo ichi: Ronda rinopinda adipocytes haisi myofibroblasts.

Chinyorwa chakaburitswa muNature Communications, chinoongorora zvingangoita mapurasitiki eadipocytes uye fibroblasts mushure mekukuvara kweganda.Uchishandisa genetic mutsara kutsvaga uye kurarama kufungidzira mune explants uye mumhuka dzakakuvadzwa, cherechedza kuti kukuvara kunokonzeresa yenguva yekutama mamiriro muadipocytes ane akasiyana akasiyana masero ekufambisa maitiro uye maitiro kubva kune fibroblasts.

Uyezve, adipocytes anotama, haabatsiri pakuumbwa kwevanga uye kuramba asiri-fibrogenic in vitro, in vivo, uye pakusimwa mumaronda mumhuka.Muchidimbu, kukuvadzwa-kunokonzerwa nekufamba-famba adipocytes kunoramba kuine mutsara-kurambidzwa uye haashanduki kana kudzokorora kuita fibrosing phenotype.Izvi zvakawanikwa zvinokanganisa maitiro ekutanga uye ekushandura mumunda wezvemishonga inovandudza, kusanganisira kupindira kwekiriniki pakugadzirisa maronda, chirwere cheshuga, uye fibrotic pathologies.

Dzvanya pano kutidzidza zvakawanda nezvechidzidzo ichi

 


Nguva yekutumira: Aug-29-2023

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