BMKGENE yakapa ONT yakarebesa kuverenga nanopore RNA sequencing uye ATAC-seq sevhisi yechidzidzo "Epigenetic uye transcriptal activation ye secretory kinase FAM20C se oncogene mu glioma", iyo yakaburitswa mu 《Journal of Genetics and Genomics》.
Ichi chidzidzo chakavaka iyo yakazara-yakareba transcriptome atlas mune maviri gliomas uye yakacherekedza kuti 22 majini anodzorwa neakazara-kureba transcriptome uye musiyano weAPA ongororo.Ongororo yeATAC-seq data inoratidza kuti ese ari maviri FAM20C neNPTN ndiwo magene ehub ane chromatin kuvhurika uye kusiyanisa kutaura.
Kupfuurirazve, in vitro uye in vivo zvidzidzo zvinoratidza kuti FAM20C inomutsa kuwanda uye metastasis yemasero eglioma.Zvichakadaro, NPTN, inoveli cancer suppressor gene, inopesana nebasa reFAM20C nekumisa kupararira uye kutama kweglioma.Kuvharika kweFAM20C nekumisa masoja ekudzivirira chirwere kunoguma nekudzoreredzwa kwemamota exenograft.Zvakare, MAX, BRD4, MYC, uye REST anowanikwa ari iwo angangoita trans-anoshanda zvinhu zvekutonga kweFAM20C.
Zvikatorwa pamwechete, mhedzisiro iyi inofumura basa reoncogenic reFAM20C muglioma uye rinoburitsa mwenje mutsva pakurapwa kweglioma nekubvisa FAM20C.
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Nguva yekutumira: Oct-20-2023