BMKGENE yakapa RNA kutevedzana nekuongorora masevhisi echidzidzo ichi "Aspergillus fumigatus inobira p11 yemunhu kuendesa fungal-ine phagosomes kune isiri-inoshatisa nzira.", iyo yakabudiswa muCell Host & Microbe.
Sarudzo yekuti endosomes inopinda munzira inoshatisa kana yekudzokorodza mumaseru emammalian yakakosha pakuuraya hutachiona, uye kusashanda kwayo kune mhedzisiro yezvirwere.
Chidzidzo ichi chakawana kuti p11 yemunhu chinhu chakakosha pasarudzo iyi.Iprotein yeHscA iripo pane conidial surface yemunhu-pathogenic fungus Aspergillus fumigatus anchors p11 pane conidia-containing phagosomes (PSs), isingabatanidzi PS maturation murevereri Rab7, uye inokonzera kusunga kwe exocytosis mediators Rab11 uye Sec15.Iyi reprogramming inodzorera PSs kune nzira isina kukanganisa, inobvumira A. fumigatus kutiza masero kuburikidza nekukura uye kudzingwa pamwe chete nekuendeswa kwekonidia pakati pemasero.
Kukosha kwekliniki kunotsigirwa nekuzivikanwa kweimwe nucleotide polymorphism munharaunda isiri-coding yeS100A10 (p11) gene inobata mRNA uye mapuroteni kutaura mukupindura A. fumigatus uye inobatanidzwa nekudzivirirwa kune invasive pulmonary aspergillosis.Izvi zvakawanikwa zvinoratidza basa rep11 mukuyananisa fungal PS kunzvenga.
Dzvanyaherekuti udzidze zvakawanda nezvechinyorwa ichi.
Nguva yekutumira: Sep-08-2023