BMKGENE yakapa Hi-C sequencing masevhisi echidzidzo ichi: 3D kusarongeka uye kurongekazve kwegenome inopa ruzivo mune pathogenesis yeasiri-doro mafuta ane chiropa chirwere (NAFLD) neyakasanganiswa Hi-C, Nanopore, uye RNA sequencing, iyo yakabudiswa muActa Pharmaceutica Sinica. B.
Muchidzidzo ichi, High-throughput chromosome conformation capture (Hi-C), Nanopore sequencing, uye RNA-sequencing (RNA-seq) miedzo yakaitwa pachiropa chemazuva ose uye NAFLD mice.
Yakasiyana-siyana muzviuru zvematunhu mhiri kwegenome zvine chekuita ne3D chromatin sangano uye genomic rearrangements, pakati pezvakajairwa neNAFLD mbeva, uye yakaratidza gene dysregulation inowanzoperekedzwa nekusiyana uku.Majini anonangwa emumiriri akaonekwa muNAFLD, akabatwa neiyo genetic rearrangements uye kukanganiswa kwesangano renzvimbo.
Izvo zvitsva zvakawanikwa zvinopa manzwisisiro mune itsva nzira dzeNAFLD pathogenesis uye inogona kupa hutsva hwemafungidziro eNAFLD kurapwa.
Dzvanyaherekuti mudzidze zvakawanda nezvechidzidzo ichi.
Nguva yekutumira: Oct-30-2023