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Evolutionary Genetics
Huwandu hwevanhu uye evolutionary genetic analysis platform inovambwa pahwaro hwechiitiko chikuru chakaunganidzwa mukati meBMK R&D timu kwemakore.Icho chishandiso chine hushamwari mushandisi kunyanya kune vaongorori vasiri hukuru mune bioinformatics.Iyi puratifomu inogonesa evolutionary genetics ine chekuita nekuongorora kwekutanga kunosanganisira phylogenetic muti kuvaka, yekubatanidza disequilibrium kuongororwa, genetic kusiyana kwekuongorora, yakasarudzika yekutsvaira ongororo, hukama hwehukama, PCA, ongororo yehuwandu hwevanhu, nezvimwe.
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circ-RNA
Circular RNA (circRNA) imhando yeRNA isiri-coding, iyo ichangobva kuwanikwa inobata basa rinokosha mukugadzirisa masangano anobatanidzwa mukuvandudza, kudzivirira kwezvakatipoteredza, nezvimwewo. Kusiyana nemutsara weRNA molecules, eg mRNA, lncRNA, 3′ uye 5′. migumo ye circRNA inobatanidzwa pamwe chete kuti iite denderedzwa chimiro, iyo inovaponesa kubva pakugayiwa kwe exonuclease uye yakagadzikana kupfuura yakawanda yemutsara RNA.CircRNA yakawanikwa iine mabasa akasiyana siyana mukugadzirisa mataurirwo ejene.CircRNA inogona kuita se ceRNA, inosunga miRNA mumakwikwi, inozivikanwa semiRNA sponge.CircRNA sequencing yekuongorora chikuva inopa simba circRNA chimiro uye ongororo yekutaura, kufanotaura kwechinangwa uye kuongororwa kwakabatana nemamwe marudzi emamorekuru eRNA.
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BSA
Bulked Segregant Analysis chikuva chine nhanho imwe chiyero chekuongorora uye ongororo yepamberi ine yakagadziridzwa paramende.BSA inzira inoshandiswa kukurumidza kuona phenotype inosanganisirwa genetic mamaki.Main workflow yeBSA ine: 1. kusarudza mapoka maviri evanhu vane phenotypes anopesana zvakanyanya;2. kubatanidza DNA, RNA kana SLAF-seq(Yakagadziridzwa neBiomarker) yevanhu vese kuti vaumbe zvikamu zviviri zveDNA;3. kudoma mitsara yakasiyana inopesana nereferensi genome kana pakati, 4. kufanotaura matunhu akabatanidzwa neED uye SNP-index algorithm;5. Kuongorora kwekushanda uye kupfumisa pamajini munharaunda dzevamiriri, nezvimwewo. Kunyanya kucherwa kwepamusoro mu data kusanganisira genetic marker screening uye primer design inowanikwawo.
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Amplicon (16S/18S/ITS)
Amplicon (16S/18S/ITS) papuratifomu inogadzirwa nemakore eruzivo mukuongororwa kweprojekiti yakasiyana-siyana, iyo ine yakajairwa ongororo yekuongorora uye kuongororwa kwemunhu: ongororo yekutanga inovhara iyo huru yekuongorora zvirimo yezvino hutachiona tsvakurudzo, zvinyorwa zvekuongorora zvakapfuma uye zvakakwana, uye mhedzisiro yekuongorora inoratidzwa muchimiro chemishumo yeprojekiti;Izvo zvemukati ongororo yemunhu zvakasiyana.Masamples anogona kusarudzwa uye ma paramita anogona kusetwa achichinjika zvinoenderana neiyo yekutanga ongororo mushumo uye chinangwa chekutsvagisa, kuti uone zvinodiwa nemunhu.Windows inoshanda sisitimu, iri nyore uye inokurumidza.
