O lo'o fa'aogaina le fa'ameamea fa'ameamea mo le fa'afanua vevela, lea e mafai ona fa'amama, fa'avasega ma fa'aputuina fa'amaumauga matrix. E tele lava ina fa'aaogaina mo le fa'avasegaina o le fa'atupuina o le fa'aaliga o gene i le va o fa'ata'ita'iga eseese.
Fa'apipi'i galuega fa'aola i fa'asologa i le faila FASTA e ala i le fa'aogaina o fa'asologa i fa'amaumauga, e aofia ai le NR, KEGG, COG, SwissProt, TrMBL, KOG, Pfam.
BLAST (Basic Local Alignment Search Tool) ose algorithm ma polokalame e suʻe ai itulagi e tutusa faʻasologa o meaola.E fa'atusatusa nei fa'asologa i fa'asologa o fa'amaumauga ma fa'atatau le taua o fuainumera.BLAST e aofia ai ituaiga meafaigaluega e fa e faʻavae i luga o le faʻasologa o ituaiga: blastn, lastp, blastx ma tblastn.