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条形 fu'a-03

Oloa

Genome-wide Association Analysis

Genome-wide association suʻesuʻega (GWAS) e faʻamoemoe e faʻamaonia fesuiaiga o kenera (genotype) e fesoʻotaʻi ma uiga faʻapitoa (phenotype).O su'esu'ega a le GWAS e su'esu'e ai fa'ailoga fa'ailoga e fa'asaga i le genome atoa o le aofa'i tele o tagata ta'ito'atasi ma va'ai fa'atasiga fa'a-genotype-phenotype e ala i su'esu'ega fa'afuainumera i le aofa'i o tagata.Ua fa'aaogaina lautele i su'esu'ega i fa'ama'i o tagata ma le ga'o ga'o galue i uiga lavelave o manu po'o la'au.


Au'aunaga Fa'amatalaga

Fa'aaliga Fa'aaliga

Lomiga Fa'apitoa

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1. Auaunaga Tulaga

● Mata'utia Poloketi: talu mai lona fa'avaeina i le 2009, ua mae'a e le BMKGENE le fiaselau o ituaiga galuega fa'atino i le faitau aofa'i o su'esu'ega a le GWAS, fesoasoani i tagata su'esu'e e fa'asalalau tala e sili atu i le 100, ma o le aofa'i o a'afiaga na o'o atu i le 500.
● Tagata suʻesuʻe tomai.
● Taamilosaga suʻesuʻe puupuu.
● Fa'amatalaga sa'o.

2. Auaunaga Fa'amatalaga

Ituaiga

Fua o Tagata

Fa'asologa o fuafuaga ma le loloto

SLAF-GWAS Fa'ata'ita'iga numera ≥200 Genome size <400M, fa'atasi ai ma ref-genome, WGS fautuaina

Genome tele ≤ 1G, 100K Fa'ailoga ma 10X

1G ≤ Genome tele ≤ 2G, 200K fa'ailoga ma 10X

Genome size > 2G, 300K Fa'ailoga ma 10X

WGS-GWAS

Fa'ata'ita'iga numera ≥200

10X mo faʻataʻitaʻiga taʻitasi

3. Filifiliga o Mea

动物1
动物2
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O ituaiga eseese, subspecies, landraces/genebanks/aiga fefiloi/sources vao

O ituaiga eseese, subspecies, landraces

Aiga afa-sib/aiga-sib-atoa/aiga vao

4. Bioinformation Iloiloga

● Su'esu'ega fa'asoso'oga a le Genome-wide
● Su'esu'ega ma su'esu'ega SNP taua
● Fa'amatalaga fa'atino ole gene sui

5. Galulue Galuega Au'aunaga

Fa'ata'ita'iga QC

Fa'ata'ita'iga mamanu

fa'ata'ita'iga tu'uina atu

Fa'ata'ita'iga tu'uina atu

Fa'ata'ita'iga pailate

RNA su'ega

Sauniuniga Faletusi

Fauga faletusi

Fa'asologa

Fa'asologa

Iloiloga fa'amaumauga

Iloiloga fa'amaumauga

A uma le fa'atauga Auaunaga

Au'aunaga pe a uma ona fa'atau


  • Muamua:
  • Sosoo ai:

  • a.Phenotype QC

    Fa'asologa o fa'asologa o taimi

    ata9

    Fuainumera fa'atusa

    ata10

    e.Su'esu'ega fa'atasi (Fa'ata'ita'iga: GEMMA, FaST-LMM, EMMAX)

    QQ Fuafuaga

    ata11

    Manhattan Plot

    Ammonia_emmax_manhattan_00

    Tausaga

    Tusitala

    IF

    Ulutala

    2022

    NC

    17.69

    Genomic faavae o giga-chromosomes ma giga-genome o laau peony Paeonia ostii

    2015

    NP

    7.43

    O tulagavae o le fale e taula ai vaega genomic e taua tele i le soya

    2018

    MP

    9.32

    O le fa'asologa atoa o le genome o se aofa'iga i le lalolagi atoa o fa'asoa fa'atosina o lo'o fa'aalia ai le fa'avae fa'avae o lo latou 'ese'esega fa'anatura.

    2022

    HR

    7.29

    Genome-wide association su'esu'ega e maua ai fa'amatalaga mole mole i le suiga fa'anatura ole lapo'a fatu meleni

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