BMKGENE na tuʻuina atu auaunaga faʻasolosolo RNA umi e le faʻamaonia mo le tusiga "O le nanoformula o le zoledronic acid ma le calcium carbonate e taulaʻi i le osteoclasts ma le faʻaliliuina o le osteoporosis", lea na lolomiina i Biomaterials, iinei, o se OCs 'microenvironment-responsive nanoplatform-HMCZP ua atiae.
O le suʻesuʻega o loʻo faʻaalia ai o le HMCZP e sili atu le aoga i le faʻalavelaveina o gaioiga o le OC matua ma le toe faʻafoʻiina o ponaivi o le ponaivi o le tino i isumu ovariectomized pe a faʻatusatusa i le togafitiga muamua.O le fa'asologa o le RNA maualuga (RNA-seq) na fa'aalia ai e mafai e le HMCZP ona fa'atonu i lalo se fa'atonuga taua mo le osteoporosis, tartrate-resistant acid phosphatase (TRAP), ma isi fa'amoemoega fa'apitoa.O nei suʻesuʻega o loʻo fautua mai ai o le faʻaaogaina o se nanoplatform atamai e faʻatatau i OCs o se fuafuaga faʻamaonia mo togafitiga o le osteoporosis.
Kilikiiineie a'oa'o atili e uiga i lenei su'esu'ega.
Taimi meli: Tes-20-2023