BMKGENE na tu'uina atu auaunaga fa'asologa fa'asologa atoa mo lenei su'esu'ega: Fa'asologa o le lymphocytes atoa le umi e tali atu i le IFN-γ fa'aalia ai se tali puipuia o le Th1-skewed i flounder (Paralichthys olivaceus), lea na lomia i le Fish & shellfish immunology.
I lenei suʻesuʻega, na faia ai le faʻasologa atoa o le transcriptome e suʻesuʻe ai kenera eseese (DEGs) ma ala faʻailo i le IFN-γ faʻaosofia lymphocytes o flounder (Paralichthys olivaceus), Th1 ma Th2 cell differentiation auala na matua faʻatamaoaigaina mai DEGs, ma o genes i le Th1 cell differentiation auala na faʻatulafonoina ma faʻamaonia.E tusa ai ma lea, na suʻesuʻeina suiga i luga o le Th1 cell differentiation marker genes ma CD4 + cell i le maeʻa ai o le IFN-γ stimulation, o faʻaiʻuga na faʻamaonia ai o le CD4 + T lymphocytes na faʻateleina tele ina ua maeʻa le IFN-γ faʻamalosi, faʻatasi ma le valu genes taua tele upregulation ma faʻateleina faʻamatalaga T-bet i lymphocytes.
I le faaiuga, o faʻaiʻuga na faʻaalia ai le faʻaogaina o le IFN-γ i luga o le Th1-type immune response, tuʻuina atu ni manatu fou i le faʻavasegaina o CD4 + T lymphocytes i teleost.
Kilikiiineie a'oa'o atili e uiga i lenei su'esu'ega.
Taimi meli: Oke-30-2023