BMKGENE idapereka njira zotsatirira ndi kusanthula RNA pa kafukufukuyu "Aspergillus fumigatus amabera p11 yamunthu kuti atsogolere ma phagosome okhala ndi mafangasi kunjira yosawononga.", yomwe idasindikizidwa mu Cell Host & Microbe.
Kusankha ngati ma endosomes alowa m'njira yowononga kapena yobwezeretsanso m'maselo a mammalian ndikofunikira kwambiri pakupha tizilombo toyambitsa matenda, ndipo kusagwira ntchito kwake kumakhala ndi zotsatira za matenda.
Kafukufukuyu adapeza kuti p11 yamunthu ndiyofunikira kwambiri pa chisankhochi.Mapuloteni a HscA omwe amapezeka pamtunda wa bowa woyambitsa matenda a anthu Aspergillus fumigatus anchors p11 pa conidia-containing phagosomes (PSs), samaphatikizapo mkhalapakati wa PS kusasitsa Rab7, ndipo amayambitsa kumangidwa kwa oyimira exocytosis Rab11 ndi Sec15.Kukonzanso uku kumapangitsanso ma PS kupita kunjira yosawonongeka, zomwe zimapangitsa kuti A. fumigatus athawe ma cell potuluka ndi kutulutsa komanso kusamutsa conidia pakati pa ma cell.
Kufunika kwachipatala kumathandizidwa ndi chidziwitso cha nucleotide polymorphism imodzi m'dera lopanda zolemba za jini la S100A10 (p11) lomwe limakhudza mRNA ndi kufotokoza kwa mapuloteni poyankha A. fumigatus ndipo zimagwirizana ndi chitetezo ku pulmonary aspergillosis.Zomwe zapezazi zikuwonetsa gawo la p11 pakuyimira kuthawa kwa mafangasi a PS.
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Nthawi yotumiza: Sep-08-2023