BMKGENE inapereka ntchito zotsatirira ma transcriptomics pa kafukufukuyu: a Drosophila homologue of mammalian adhesion GPCRs, amakhudzidwa ndi zochita za antitumor ku ma cell a oncogenic mu ntchentche, zomwe zidasindikizidwa mu PNAS, mthl1.
Mu kafukufukuyu, ntchentche zazimuna zazikulu zidabayidwa ndi ma OCs, ndipo kutsatizana kwa malo pa ntchentche zozizira kumachitika.Kubaya ma OCs mu ntchentche zaamuna kumapangitsa kuti ntchentche zokhala ndi ma gene zikhale ndi ma gene fide G-coupled proteins, pomwe jini ya methuselah-ngati 1 ndi yotchuka.
Kupyolera mu kuphatikizika kwa chibadwa cha jini ya mthl1 (kutayika kwa ntchito ndi kufotokoza mopambanitsa kwa mthl1), zolembedwa kuti ndithudi jini ili ndi antiproliferative effect.Kupitilira apo, onetsani kuti mthl1 imawongolera kuwonetsa kuchuluka kwa ma jini olembera ma chemoreceptors ndi majini omwe amakhudzidwa pakuwongolera chitukuko.Anazindikira njira zodzitetezera ntchentche motsutsana ndi zotupa popanda kusintha chitetezo chokwanira.
Dinani apa kuti mudziwe zambiri za kafukufukuyu
Nthawi yotumiza: Aug-10-2023