Nkhani Yofalitsidwa

DNA methylation ndi imodzi mwazosinthidwa kwambiri za epigenetic.Zimagwira ntchito yofunika kwambiri pakukhazikika kwa ma genome, kuwongolera kalembedwe ka jini, komanso kakulidwe kakhalidwe.Kulemba kwa majini kumatsimikiziridwa ndi mawonekedwe awo a methylation, omwe ali ndi milingo yotsika ya methylation yokhudzana ndi mawonekedwe a jini komanso milingo yayikulu ya methylation yokhudzana ndi kuletsa jini.

Kuphatikiza ma jini amtundu wa bisulfite sequencing (WGBS) ndi RNA-seq data amalola kusanthula mwatsatanetsatane za genome ndi transcriptome, kuwulula njira zoyendetsera jini, ndikuzindikira njira zatsopano zamoyo ndi zolemba zakale.Chiyanjano pakati pa transcriptome ndi methylation sequencing data zitha kukhazikitsidwa kutengera majini, kuphatikiza ma dataset onse pogwiritsa ntchito majini ngati mlatho.

Kusanthula uku kumathandizira kumvetsetsa kugwirizana pakati pa DNA methylation ndi mawu amtundu, kuzindikira majini omwe amakhudzidwa ndi methylation, ndikufufuza zotsatira zakutsika.

Khalani omasuka kulumikizana ndi BMKGENE kuti mumve zambiri pa kafukufuku wa epigenetic.