BMKGENE nyere usoro Nanopore RNA ogologo oge ONT na ọrụ ATAC-seq maka ọmụmụ ihe "Epigenetic and transcriptional activation of the secretory kinase FAM20C dị ka oncogene na glioma", nke e bipụtara na ''Journal of Genetics and Genomics》.
Ọmụmụ ihe a rụrụ atlas transcriptome zuru oke na gliomas jikọtara ọnụ wee hụ na a na-ahazi mkpụrụ ndụ ihe nketa 22 site na transcriptome ogologo na nyocha APA dị iche.Nyocha nke data ATAC-seq na-ekpughe na ma FAM20C na NPTN bụ mkpụrụ ndụ ihe nketa nwere oghere chromatin na ngosipụta dị iche.
Ọzọkwa, ọmụmụ in vitro na in vivo na-atụ aro na FAM20C na-akpali mmụba na metastasis nke mkpụrụ ndụ glioma.Ka ọ dị ugbu a, NPTN, mkpụrụ ndụ ihe na-egbochi kansa cancer, na-emegide ọrụ FAM20C site na igbochi ma mmụba na mbugharị nke glioma.Mgbochi nke FAM20C site na iwepu ọgwụ mgbochi ọrịa na-ebute nlọghachi azụ nke etuto xenograft.Ọzọkwa, MAX, BRD4, MYC, na REST ka achọpụtara na ọ bụ ihe ndị nwere ike ime mgbanwe maka iwu FAM20C.
N'ịchịkọta ọnụ, nsonaazụ ndị a na-ekpughe ọrụ oncogenic nke FAM20C na glioma ma mee ka ìhè ọhụrụ na ọgwụgwọ glioma site na ikpochapụ FAM20C.
PịaEbe aka ịmatakwu gbasara ọmụmụ ihe a
Oge nzipu: Ọktoba 20-2023