BMKGENE nyere RNA usoro na nyocha ọrụ maka ọmụmụ ihe a "Aspergillus fumigatus na-apụnara mmadụ p11 iji megharịa phagosomes nwere fungal na ụzọ na-adịghị emebi emebi.“nke e bipụtara na Cell Host & Microbe .
Mkpebi ma endosomes na-abanye n'ụzọ mmebi ma ọ bụ imegharịgharị n'ime sel anụ mammalian bụ ihe dị mkpa dị mkpa maka igbu nje, na arụrụ ọrụ ya nwere nsonaazụ ọrịa.
Ọmụmụ ihe a chọpụtara na p11 mmadụ bụ ihe dị mkpa maka mkpebi a.Protein HscA dị na conidial elu nke ero mmadụ-pathogenic Aspergillus fumigatus anchors p11 na conidia nwere phagosomes (PSs), na-ewepu PS maturation mediator Rab7, na-akpalite njikọ nke exocytosis mediators Rab11 na Sec15.Ntugharị a na-emegharị PS na ụzọ na-adịghị emebi emebi, na-ekwe ka A. fumigatus gbanarị mkpụrụ ndụ site na mpụta na ịchụpụ yana ịnyefe conidia n'etiti sel.
A na-akwado nkwado ahụike site na njirimara nke otu nucleotide polymorphism na mpaghara na-abụghị koodu nke S100A10 (p11) gene nke na-emetụta mRNA na okwu protein na nzaghachi A. fumigatus ma jikọta ya na nchebe megide aspergillosis pulmonary invasive.Nchọpụta ndị a na-ekpughe ọrụ nke p11 na mgbasa ozi fungal PS evasion.
PịaEbe aka ịmatakwu gbasara akụkọ a.
Oge nzipu: Sep-08-2023