Methylation DNA bụ otu n'ime mgbanwe epigenetic a na-enyocha nke ọma.Ọ na-arụ ọrụ dị oke mkpa na nkwụsi ike genome, nhazi ederede mkpụrụ ndụ ihe nketa, na mmepe àgwà.A na-ekpebi ntụgharị mkpụrụ ndụ ihe nketa site na ọnọdụ methylation ha, yana ọkwa methylation dị ala jikọtara ya na okwu mkpụrụ ndụ ihe nketa yana ọkwa methylation dị elu jikọtara ya na ịgbachi nkịtị.
Ịmekọrịta usoro nke genome bisulfite dum (WGBS) na data RNA-seq na-enye ohere maka nyocha zuru oke nke genome na transcriptome, na-ekpughe usoro nhazi usoro mkpụrụ ndụ ihe nketa, na ịchọpụta usoro ndu ọhụrụ na ndị na-ahụ maka biomarkers.Enwere ike ịmepụta njikọ dị n'etiti transcriptome na methylation sequencing data dabere na mkpụrụ ndụ ihe nketa, na-ejikọta ma datasets site na iji mkpụrụ ndụ ihe nketa dị ka akwa mmiri.
Nyocha a na-enyere aka ịghọta njikọ dị n'etiti DNA methylation na okwu mkpụrụ ndụ ihe nketa, chọpụta mkpụrụ ndụ ihe nketa nke methylation na-emetụta, na nyochaa mmetụta arụ ọrụ nke ala.
Enwere onwe gị ịkpọtụrụ BMKGENE maka nghọta enweghị atụ na nyocha epigenetic.
Oge nzipu: Dec-05-2023