BMKGENE muab RNA sequencing thiab tsom xam cov kev pab cuam rau txoj kev tshawb no "Aspergillus fumigatus hijacks tib neeg p11 rau redirect fungal-muaj phagosomes rau txoj kev tsis-degradative", uas tau luam tawm hauv Cell Host & Microbe .
Qhov kev txiav txim siab seb cov endosomes nkag mus rau hauv txoj kev degradative los yog rov ua dua txoj hauv kev hauv cov tsiaj nyeg yog qhov tseem ceeb rau kev tua kab mob, thiab nws qhov ua tsis tau zoo muaj qhov tshwm sim ntawm pathological.
Txoj kev tshawb no pom tias tib neeg p11 yog qhov tseem ceeb rau kev txiav txim siab no.HscA protein tam sim no nyob rau ntawm conidial nto ntawm tib neeg-pathogenic fungus Aspergillus fumigatus anchors p11 ntawm conidia-muaj phagosomes (PSs), tsis suav nrog PS maturation mediator Rab7, thiab ua rau kev khi ntawm exocytosis mediators Rab11 thiab Sec15.Qhov no reprogramming redirects PSs mus rau txoj kev uas tsis yog-degradative, cia A. fumigatus khiav tawm hlwb los ntawm outgrowth thiab expulsion raws li zoo raws li hloov ntawm conidia ntawm hlwb.
Qhov kev soj ntsuam tseem ceeb tau txais kev txhawb nqa los ntawm kev txheeb xyuas ntawm ib qho nucleotide polymorphism nyob rau hauv cheeb tsam uas tsis yog-coding ntawm S100A10 (p11) noob uas cuam tshuam rau mRNA thiab cov lus qhia protein nyob rau hauv cov lus teb rau A. fumigatus thiab cuam tshuam nrog kev tiv thaiv kab mob pulmonary aspergillosis.Cov kev tshawb pom no qhia txog lub luag haujlwm ntawm p11 hauv kev kho cov fungal PS evasion.
Nyemntawm nokom paub ntau ntxiv txog kab lus no.
Post lub sij hawm: Sep-08-2023