Hoʻolaha ʻia

Hāʻawi ʻo BMKGENE i nā lawelawe hoʻokaʻina a me ka nānā ʻana i ka RNA nui no kēia noiʻi: ʻAʻole myofibroblasts nā adipocytes infiltrating ʻeha.

Ua paʻi ʻia ka ʻatikala ma Nature Communications, e ʻimi ana i ka plasticity o nā adipocytes a me nā fibroblasts ma hope o ka ʻeha ʻili.Ke hoʻohana nei i ka ʻimi ʻana o ka moʻopuna a me ke kiʻi ola i loko o nā explants a me nā holoholona ʻeha, e nānā i ka hōʻeha ʻana i kahi moku neʻe transient i adipocytes me nā hiʻohiʻona neʻe a me nā ʻano hana mai nā fibroblasts.

Eia kekahi, ʻo nā adipocytes migratory, ʻaʻole kōkua i ka hoʻokumu ʻana i ka ʻili a noho mau i ka non-fibrogenic in vitro, in vivo, a ma ka hoʻololi ʻana i nā ʻeha i nā holoholona.ʻO ka hōʻuluʻulu manaʻo, ʻo nā adipocytes migratory i hōʻeha ʻia i ka hōʻeha ʻia e hoʻopaʻa ʻia i ka laina a ʻaʻole e hoʻohuli a hoʻonohonoho hou i kahi fibrosing phenotype.Hoʻopili nui kēia mau ʻike i nā hoʻolālā kumu a me ka unuhi ʻana i ka lāʻau lapaʻau regenerative, me nā hana lapaʻau no ka hoʻoponopono ʻana i nā ʻeha, ka maʻi diabetes, a me nā maʻi fibrotic.

Kaomi maanei noe aʻo hou e pili ana i kēia haʻawina