Hāʻawi ʻo BMKGENE i nā lawelawe hoʻonohonoho transcriptome holoʻokoʻa no kēia haʻawina: ʻO ke kaʻina hana transcriptome holoʻokoʻa o nā lymphocytes pane i ka IFN-γ e hōʻike ana i ka Th1-skewed immune pane i ka flounder (Paralichthys olivaceus), i paʻi ʻia ma Fish & shellfish immunology.
Ma kēia noiʻi ʻana, ua hana ʻia ke kaʻina transcriptome holoʻokoʻa no ka nānā ʻana i nā ʻano genes i hōʻike ʻia (DEG) a me nā ala hōʻailona i ka IFN-γ stimulated lymphocytes of flounder (Paralichthys olivaceus), Th1 a me Th2 cell differentiation alahele i hoʻonui nui ʻia mai DEGs, a ua hoʻoponopono ʻia a hōʻoia ʻia nā genes i loko o ke ala ʻokoʻa cell Th1.No laila, ua noiʻi ʻia nā ʻano like ʻole o ka Th1 cell differentiation marker genes a me CD4 + cell ma hope o ka hoʻoulu ʻana o IFN-γ, ua hōʻoia nā hopena i ka nui o ka CD4 + T lymphocytes ma hope o ka hoʻoulu ʻana o IFN-γ, hele pū ʻia me ʻewalu mau genes upregulation nui a hoʻonui i ka hōʻike T-bet i nā lymphocytes.
I ka hopena, ua hōʻike nā hopena i ka hoʻokomo ʻana o IFN-γ ma ka Th1-type immune response, e hāʻawi ana i nā hiʻohiʻona hou i ka hoʻokaʻawale ʻana i nā lymphocytes CD4 + T ma teleost.
Kaomimaaneie aʻo hou e pili ana i kēia haʻawina.
Ka manawa hoʻouna: ʻOkakopa-30-2023