Hāʻawi ʻo BMKGENE iā ONT lōʻihi heluhelu nanopore RNA sequencing a me ATAC-seq lawelawe no ke aʻo ʻana "Epigenetic and transcriptional activation of the secretory kinase FAM20C ma ke ʻano he oncogene i glioma", i paʻi ʻia ma ka 《Journal of Genetics and Genomics》.
Ua kūkulu kēia haʻawina i ka atlas transcriptome holoʻokoʻa i nā gliomas paʻa a ʻike ʻia he 22 mau genes i hoʻoponopono ʻia e ka transcriptome holoʻokoʻa a me ka ʻokoʻa APA ʻokoʻa.Hōʻike ka ʻikepili o ka ATAC-seq ʻo FAM20C a me NPTN nā genes hub me ka wehe ʻana o ka chromatin a me ka hōʻike ʻokoʻa.
Eia kekahi, hōʻike ʻia nā haʻawina in vitro a me in vivo e hoʻoulu ʻia ka FAM20C i ka hoʻonui a me ka metastasis o nā cell glioma.I kēia manawa, kū'ē ka NPTN, kahi moʻo suppressor cancer novel, i ka hana o FAM20C ma ke kāohi ʻana i ka hoʻonui a me ka neʻe ʻana o ka glioma.ʻO ka paʻa ʻana o FAM20C ma ka hoʻokaʻawale ʻana i nā antibodies e hopena i ka regression o nā maʻi maʻi xenograft.Eia kekahi, ʻike ʻia ʻo MAX, BRD4, MYC, a me REST nā kumu trans-active kūpono no ka hoʻoponopono ʻana o FAM20C.
Hoʻohui pū ʻia, ʻike kēia mau hopena i ka hana oncogenic o FAM20C i ka glioma a hoʻomālamalama hou i ka mālama ʻana i ka glioma ma ka hoʻopau ʻana i ka FAM20C.
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Ka manawa hoʻouna: Oct-20-2023