Binciken Ƙungiya mai Faɗi

Hoton da aka Fitar da Faɗin Ƙungiya ta Genome

Nazarin ƙungiyar genome-wide (GWAS) yana nufin gano bambance-bambancen kwayoyin halitta (genotype) waɗanda ke da alaƙa da takamaiman halaye (phenotype).Nazarin GWAS yana bincika alamomin kwayoyin halitta sun haye dukkanin kwayoyin halittar mutane masu yawa kuma yana tsinkayar ƙungiyoyin genotype-phenotype ta ƙididdigar ƙididdiga a matakin yawan jama'a.An yi amfani da shi sosai a cikin bincike kan cututtukan ɗan adam da aikin haƙar ma'adinan kwayoyin halitta akan hadaddun halaye na dabbobi ko tsirrai.

Tuntube Mu

Cikakkun Sabis

Sakamakon Demo

Fitar Bugawa

1. Amfanin Sabis

Yawan Ayyukan Ayyuka: Tun lokacin da aka kafa shi a cikin 2009, BMKGENE ya kammala ɗaruruwan ayyukan jinsuna a cikin binciken GWAS na yawan jama'a, ya taimaka wa masu bincike don buga labarai fiye da 100, kuma tasirin tasirin tasirin ya kai 500.
● Kwararrun manazarta.
● gajeren zagayowar bincike.
● Ma'adinan bayanai daidai.

2. Bayanin Sabis

Nau'in	Girman Yawan Jama'a	Dabarun tsarawa da zurfi
SLF-GWAS	Misalin lamba ≥200	Girman kwayoyin halitta <400M, tare da ref-genome, WGS ana ba da shawarar
		Girman Genome ≤ 1G, 100K Tags da 10X
		1G ≤ Girman Genome ≤ 2G, 200K Tags da 10X
		Girman Genome> 2G, Tags 300K da 10X
WGS-GWAS	Misalin lamba ≥200	10X ga kowane samfurin

3. Zaɓin kayan aiki

Daban-daban iri, kasaftawa, landbles / Genebanks / hade da iyalai / albarkatun daji

Daban-daban iri-iri, nau'ikan nau'ikan, nau'ikan ƙasa

Half-sib iyali/cikakkiyar iyali / albarkatun daji

4. Binciken Halittu

● Binciken ƙungiyoyi masu fa'ida
● Bincike da nunawa na SNP masu mahimmanci
● Bayanin aiki na jinsin ɗan takara

5. Gudun Aikin Sabis

Gwajin ƙira

Samfurin bayarwa

RNA cirewa

Gina ɗakin karatu

Jeri

Binciken bayanai

Bayan-sayar da sabis

Na baya: Single-nucleus RNA Sequencing

Na gaba:

a.Phenotype QC

Histogram na rarraba mita

Ƙididdiga na Phenotype

b.Binciken ƙungiyoyi (Model: GEMMA, FaST-LMM, EMMAX)

Tsarin QQ

Manhattan Plot

Shekara	Jarida	IF	Take
2022	NC	17.69	Tsarin genomic na giga-chromosomes da giga-genome na itacen peony Paeonia ostii
2015	NP	7.43	Sawun gida yana kafa yankuna masu mahimmancin aikin gona a cikin waken soya
2018	MP	9.32	Gabaɗaya-genome mai kama da tarin nau'ikan nau'ikan fyade a duniya yana bayyana tushen asalin halittar halittarsu
2022	HR	7.29	Binciken haɗin gwiwar genome-fadi yana ba da fahimtar kwayoyin halitta game da bambancin yanayin girman irin kankana