BMKGENE ya ba da jerin ayyukan RNA mai yawa da sabis na bincike don wannan binciken: Rauni masu kutsawa adipocytes ba su ne myofibroblasts ba.
An buga labarin a cikin Nature Communications, yana bincika yuwuwar filastik adipocytes da fibroblasts bayan rauni na fata.Yin amfani da bin diddigin jinsin halittu da kuma raye-rayen hoto a cikin ɓangarorin da kuma a cikin dabbobin da suka ji rauni, lura cewa rauni yana haifar da yanayin ƙaura na wucin gadi a cikin adipocytes tare da nau'ikan ƙaura na sel da halaye na fibroblasts.
Bugu da ƙari, adipocytes masu ƙaura, ba sa taimakawa ga samuwar tabo kuma suna zama marasa fibrogenic a cikin vitro, a cikin vivo, da kuma lokacin dasawa zuwa raunuka a cikin dabbobi.A taƙaice, adipocytes na ƙaura da ke haifar da rauni sun kasance masu ƙuntatawa na layi-layi kuma ba sa haɗuwa ko sake tsara su cikin nau'in fibrosing phenotype.Wadannan binciken sun yi tasiri sosai akan dabarun asali da na fassara a cikin filin magani na farfadowa, ciki har da ayyukan asibiti don gyaran raunuka, ciwon sukari, da cututtukan fibrotic.
Danna nan donƙarin koyo game da wannan binciken
Lokacin aikawa: Agusta-29-2023