BMKGENE ya ba da jerin dogon karanta nanopore RNA na ONT da sabis na ATAC-seq don binciken "Epigenetic and transcriptional activation of secretory kinase FAM20C a matsayin oncogene a cikin glioma", wanda aka buga a cikin ''Journal of Genetics and Genomics》.
Wannan binciken ya gina cikakken tsawon kwafin atlas a cikin gliomas guda biyu kuma ya lura cewa kwayoyin halittar 22 suna haɓaka ta hanyar cikakken kwafin kwafi da bambancin nazarin APA.Binciken bayanan ATAC-seq ya nuna cewa duka FAM20C da NPTN sune jigon kwayoyin halitta tare da buɗewar chromatin da bayyana bambanci.
Bugu da ari, in vitro da in vivo binciken yana nuna cewa FAM20C yana haɓaka haɓakawa da haɓakar ƙwayoyin glioma.A halin yanzu, NPTN, wani sabon labari mai hana cutar kansa, yana magance aikin FAM20C ta hanyar hana haɓakawa da ƙaura na glioma.Toshewar FAM20C ta hanyar kawar da ƙwayoyin rigakafi yana haifar da koma baya na ciwan xenograft.Bugu da ƙari, MAX, BRD4, MYC, da REST an gano su ne yuwuwar abubuwan da za su iya canzawa don ƙa'idar FAM20C.
A hade tare, waɗannan sakamakon sun buɗe aikin oncogenic na FAM20C a cikin glioma kuma suna ba da sabon haske kan maganin glioma ta hanyar kawar da FAM20C.
Dannanandon ƙarin koyo game da wannan binciken
Lokacin aikawa: Oktoba-20-2023