BMKGENE ya ba da jerin RNA da sabis na bincike don wannan binciken "Aspergillus fumigatus yayi garkuwa da ɗan adam p11 don karkatar da phagosomes masu ɗauke da fungal zuwa hanyar mara lalacewa.“Wanda aka buga a cikin Cell Host & Microbe .
Shawarar ko endosomes sun shiga hanyar lalata ko sake yin amfani da su a cikin sel masu shayarwa yana da mahimmancin mahimmanci ga kashe ƙwayoyin cuta, kuma rashin aikin sa yana da sakamakon cutar.
Wannan binciken ya gano cewa ɗan adam p11 muhimmin abu ne ga wannan shawarar.Sunan furotin na HscA da ke kan saman conidial na naman gwari na ɗan adam Aspergillus fumigatus anchors p11 akan conidia-dauke da phagosomes (PSs), ban da PS maturation matsakanci Rab7, kuma yana haifar da ɗaurin matsakanci na exocytosis Rab11 da Sec15.Wannan reprogramming yana tura PSs zuwa hanyar da ba ta lalacewa ba, yana barin A. fumigatus ya tsere wa sel ta hanyar girma da fitarwa da kuma canja wurin conidia tsakanin sel.
Abubuwan da suka dace na asibiti suna tallafawa ta hanyar gano nau'in polymorphism na nucleotide guda ɗaya a cikin yankin da ba codeing na S100A10 (p11) gene wanda ke rinjayar mRNA da furcin furotin a mayar da martani ga A. fumigatus kuma yana hade da kariya daga aspergillosis na huhu.Wadannan binciken sun nuna rawar da p11 ke takawa a cikin tsaka-tsaki na fungal PS gujewa.
Dannanandon ƙarin koyo game da wannan labarin.
Lokacin aikawa: Satumba-08-2023