BMKGENE ya ba da sabis na jerin abubuwan Hi-C don wannan binciken: 3D disorganization da sake tsara kwayoyin halitta suna ba da haske game da pathogenesis na cututtukan hanta maras giya (NAFLD) ta hanyar haɗakarwar Hi-C, Nanopore, da RNA, wanda aka buga a Acta Pharmaceutica Sinica. B.
A cikin wannan binciken, an gudanar da ɗaukar nauyin chromosome mai girma (Hi-C), jerin Nanopore, da RNA-sequencing (RNA-seq) auna hanta na al'ada da mice NAFLD.
An gano bambance-bambance a cikin dubban yankuna a fadin kwayoyin halitta dangane da ƙungiyar chromatin na 3D da sake tsara tsarin kwayoyin halitta, tsakanin al'ada da mice NAFLD, da bayyanar dysregulation na kwayoyin halitta akai-akai tare da waɗannan bambance-bambancen.An gano kwayoyin halittar da aka yi niyya a cikin NAFLD, wanda aka yi tasiri ta hanyar sake tsara kwayoyin halitta da rushewar kungiyar sararin samaniya.
Sabbin abubuwan da aka gano suna ba da haske game da sabbin hanyoyin fasahar NAFLD kuma suna iya samar da sabon tsarin ra'ayi don maganin NAFLD.
Dannanandon ƙarin koyo game da wannan binciken.
Lokacin aikawa: Oktoba-30-2023