BMKGENE provided bulk RNA sequencing and analysis services for this study: Wound infiltrating adipocytes are not myofibroblasts.
The article was published in Nature Communications, it explores the potential plasticity of adipocytes and fibroblasts after skin injury. Using genetic lineage tracing and live imaging in explants and in wounded animals, observe that injury induces a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviors from fibroblasts.
Furthermore, migratory adipocytes, do not contribute to scar formation and remain non-fibrogenic in vitro, in vivo, and upon transplantation into wounds in animals. In summary, the injury-induced migratory adipocytes remain lineage-restricted and do not converge or reprogram into a fibrosing phenotype. These findings broadly impact basic and translational strategies in the regenerative medicine field, including clinical interventions for wound repair, diabetes, and fibrotic pathologies.
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Post time: Aug-29-2023