BMKGENE provided sequencing and analysis services of 16S rDNA amplicon and metabolomics for the study titled “Maternal vitamin B1 is a determinant for the fate of primordial follicle formation in offspring”, which was published in Nature Communications.
The study found that in mice, a maternal high-fat diet during pregnancy impaired the preservation of the ovarian primordial follicle pool in female offspring, which was accompanied by mitochondrial dysfunction of germ cells. This was due to a decrease in maternal gut microbiota-related vitamin B1, which was restored through vitamin B1 supplementation.
In summary, the study highlights the role of maternal high-fat diet in influencing offspring oogenic fate and suggests that vitamin B1 could be a promising therapeutic approach for protecting offspring health.
Click here to learn more about this study.
Post time: Dec-20-2023