The article published in Microbiome, Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation, through gut microbiota transplantation experiment, Aeromonas colonization and LPS or butyrate supplementation experiment, evaluated gut microbes and their metabolites mediate the ameliorative effects of melatonin on sleep deprivation-induced cognitive impairment and revealed a feasible mechanism of melatonin in improving sleep deprivation-induced inflammatory response in the hippocampus and spatial memory impairment.
BMKGENE provided full-length microbial amplicon sequencing and non-target metabolome testing services for this study.
Post time: May-12-2023