The article, titled “Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma”, was published in Journal of Genetics and Genomics.
This study constructed the full-length transcriptome atlas in paired gliomas. Analysis of ATAC-seq data reveals that both FAM20C and NPTN are the hub genes with chromatin openness and differential expression.
Further, vitro and vivo studies suggest that FAM20C stimulates the proliferation and metastasis of glioma cells.
All in all, these results uncover the oncogenic role of FAM20C in glioma and shed new light on the treatment of glioma by abolishing FAM20C.
BMKGENE provided sequencing and analysis services of ONT full-length transcriptome and ATAC for this study.
If you would like to learn more about this study, access this link. For more information on our sequencing and bioinformatics services, you can talk to us here.
Post time: Aug-09-2024