Exploring the Role of circRNAs in Cirrhotic Cardiomyopathy
A recent article published in International Immunopharmacology delves into circRNAs and their impact on Cirrhotic Cardiomyopathy (CCM) both before and after liver transplantation.
This groundbreaking study utilized advanced gene sequencing techniques to find the circRNA expression profiles of patients affected by CCM, shedding light on potential diagnostic and therapeutic avenues. The comprehensive bioinformatics analysis highlighted the potential involvement of mTOR and MAPK signaling pathways in the pathogenesis of CCM.
Unveiling Key Players
Constructing a circRNA-miRNA-mRNA interaction network unveiled crucial players, with hsa-miR-197-3p, hsa-miR-483-3p, and hsa-miR-885-3p taking center stage. Notably, hsa-miR-483-3p emerged as a key miRNA, suggesting its significant role in the regulation of CCM.
Implications for Diagnosis and Treatment
The study’s conclusion is that circRNAs play a pivotal regulatory role in the onset and progression of CCM, both before and after liver transplantation. Understanding their potential biological functions is deemed essential for the diagnosis and treatment of CCM. The identified circRNAs and associated miRNAs, especially hsa-miR-483-3p, present promising targets for further research and therapeutic interventions.
BMKGENE’s Contribution
BMKGENE provided invaluable sequencing and analysis services for this study. If you would like to know how we could help you with your future project, contact us now.
Post time: Apr-03-2024