The decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. The article, titled “Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway”, was published in Cell Host Microbe. This study finds that human p11 is a critical factor for this decision.
The clinical relevance is supported by the identification of a single nucleotide polymorphism in the non-coding region of the S100A10 (p11) gene that affects mRNA and protein expression in response to A. fumigatus and is associated with protection against invasive pulmonary aspergillosis. These findings reveal the role of p11 in mediating fungal PS evasion.
BMKGENE provided RNA sequencing services for this study.
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Post time: Sep-23-2024